L (Arg/Lys), treated cells H (Arg/Lys), untreated control cells. SILAC (L/H) ratios) of the human 26S subunits purified from 293 Rpn11-HTBH cells in the presence and absence of H 2O 2 treatment. A, the general workflow of the SILAC-based quantitative XAP-MS strategy. MS oxidative stress proteasome protein cross-linking protein purification protein–protein interaction structural model.ĭetermination of 26S proteasome disassembly and enrichment of Ecm29 upon oxidative stress in human cells. These results enabled us to propose a structural model in which Ecm29 intrudes on the interaction between the 20S core particle and the 19S regulatory particle in the 26S proteasome, disrupting the proteasome structure in response to oxidative stress. Importantly, using a disuccinimidyl sulfoxide-based cross-linking MS platform, we mapped the interactions of Ecm29 within itself and with proteasome subunits and determined the architecture of the Ecm29-proteasome complex with integrative structure modeling. Our results indicate that the adapter protein Ecm29 is the main proteasome-interacting protein responsible for stress-triggered remodeling of the 26S proteasome in human cells. Moreover, we developed and employed a new proteomic approach, XAP ( in vivo cross-linking-assisted affinity purification), coupled with stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative MS, to capture and quantify several weakly bound proteasome-interacting proteins and examine their roles in stress-mediated proteasomal remodeling. To this end, we investigated H 2O 2 stress-induced molecular changes of the human 26S proteasome and determined that stress-induced 26S proteasome disassembly is conserved from yeast to human. To understand stress-associated human pathologies, it is important to uncover the molecular events underlying the regulation of proteasomes upon oxidative stress. Proteasomes are multi-subunit proteases critical for the removal of oxidatively damaged proteins. Oxidative stress has been implicated in multiple human neurological and other disorders.
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![]() For half a millennium after the fall of the Han Dynasty (220 AD), Buddhism became firmly implanted in China. ![]() There grew up side-by-side the Buddhist and Taoist temples, Muhammedan mosques, Manichean and Nestorian churches.īuddhism reached China in around 120 BC by means of both merchants and missionaries along the caravan routes through Central Asia into China. There were priests from India, officials and merchants from Persia and the kingdoms of Central Asia, Turks, Arabs and traders from Mesopotamia. As Sickman and Soper describe it, the streets were filled with the cosmopolitan populace befitting the capital of such an extensive empire. In the seventh and eighth centuries, the Chinese capital Chang’An (modern Xi’An) was the greatest city in the world. A never-ending stream of camel caravans carried Chinese goods across the highways of Central Asia.” On the return journey, caravans carried exotic goods back through the gates of the Great Wall. A groundbreaking 1956 book by Laurence Sickman and Alexander Soper, entitled The Art and Architecture of China, explains that “goods from China were to be found in market towns throughout the Near and Middle East. Moreover, Central Asia developed its own paper industry, also based on improved-upon Chinese technology, substituting cotton fiber for silk.ĭuring the Tang Dynasty (618–907 AD) trade with Central Asia reached new heights. Although silk textiles were China’s main export to Central Asia for a long period, the region also had its own ancient textile industry, much of it for export. The main body of China’s exports consisted of silk yarn and silk fabrics. lapis lazuli), gold, silverware, and glassware. China’s imports from Central Asia consisted of a wide variety of goods, including warhorses, spices, fragrances, wine, precious stones (e.g. The Silk Road developed during the Han Dynasty (206 BC–220 AD), when Europe was united under Roman rule. “Inner Turkestan” in Xinjiang and “Outer Turkestan” in Central Asia have been intimately interconnected for over two millenia through trade and the inter-mingling of the diverse people who live in the Greater Turkestan region. It spans a territory that stretches for around 1,000 miles from Yu Men Guan (“Jade Gate”) in China’s Gansu province to the Oxus River (Amu Darya) in western Uzbekistan, and is divided in two by the Tian Shan-Kun Lun Mountain Ranges. The Western Region (Xi Yu), or Greater Turkestan, is the heartland of the Silk Road by land. ![]() It is with this in mind that I will undertake to examine in this essay some aspects of China’s relationship with the territories along the Silk Road prior to the global transformation set in motion by the Industrial Revolution in Great Britain. If all civilizations can uphold inclusiveness, the so-called ‘clash of civilizations’ will be out of the question and the harmony of civilizations will become reality. In his March 2014 address at UNESCO, President Xi stressed the importance of an appreciation of history for mutual understanding: history tells us that only by interacting with, and learning from, others can a civilization enjoy full vitality. Xinjiang and the South China Sea constitute China’s “doorways” into Central and Southeast Asia, respectively. It has had deep long-term trade and cultural interactions with Central Asia through Xinjiang, and with Southeast Asia through the South China Sea (Nan Hai). For over 2,000 years, China has had a close relationship with the surrounding regions of Asia. He holds the Chong Hua Chair in Chinese Development at the University of CambridgeĬHINA’S President Xi Jinping has made the policy of the ‘New Silk Road by Land and Sea,’ which would connect the Middle Kingdom with the West, a key part of China’s international relations. Peter Nolan is Director of the Chinese Executive Leadership Programme (CELP) and Director of the University of Cambridge’s Centre of Development Studies. The Silk Road by Land and Sea - A Historical Perspective ![]() Though they shouldn’t be considered a quick fix, these medications can be a useful tool to support weight management when combined with regular physical activity and a nutritious diet. ![]() These medications are designed for people who haven’t been able to achieve weight loss through other methods, including diet or lifestyle changes. Similarly, setmelanotide (Imcivree), is intended to treat obesity caused by certain genetic disorders. Most weight loss medications are approved for adults with obesity or overweight and at least one weight-related condition, such as: We reviewed all of the weight loss medications that are currently available, including how they work, who they might be appropriate for, research on their effectiveness, and potential safety concerns. When paired with other lifestyle changes and taken under the supervision of a healthcare professional, these drugs may offer an effective way to lower your weight.
Some of the other reviewers have mentioned that they only use it as a backup clock because it doesn't plug into the wall and its only power source is a AA battery. But for the price of some of the other clocks I may have well just bought a new cell phone. I looked at some fancier options like the wooden digital clocks because I'm an adult now and should have something more modern looking. If anything could have woken a teenager from a dead sleep at 6:30 in the morning to get ready for school, it was this clock. I ordered this alarm clock because I used to have a gold one exactly like it when I was a kid and remember the 'wake the dead' bell vividly. Because of this, it has become an unreliable source of an alarm, since most of the time it's low or dead when I wake up in the morning. ![]() I let the battery in the phone get to 0% and replace it with one that's fully charged. I have used my cell phone as an alarm clock for years, but recently the phone I have has lost all its charging properties, so I have to have 3 different batteries and have one backup, one in the phone discharging, and one on a wall charger at all times. However, if you're the type of heavy sleeper that can sleep through literal fire alarms ringing throughout a dorm hall, for example, buy the Sonic Boom. The Sonic Boom is pricier, so if you're just looking for something simple and loud, I would stick with this Sharp Analog clock. Additionally, if the Sharp Analog clock somehow isn't loud enough for you, the Sonic Boom boasts 102db (not sure about the accuracy of this, but I do know it's crazy loud). This is a good option if you share a room and don't want to wake the other person up. Side note: If you're looking for a less intrusive alarm that can definitely wake you up without sound, there's the Sonic Boom (Amazon link: Sonic Alert SBJ525ss Sonic Bomb Jr., Black/Red ), which shakes your bed very violently to get you up. I'm not sure why, but this never bothered me. nine on the dot), it rings more precisely than when set for an interval in between. This doesn't really bother me, and I find that if you set it for an exact time (e.g. You can see that more clearly in the video. If you were to set it for 3:30, it may ring a little past three. One problematic aspect is that the alarm doesn't ring exactly at the exact time you set it for. One plus is that there are no lights emitting from this clock, as found in your typical digital alarm clock. At night, when everything is still and quiet, it is more obvious. It's not very loud, and I don't notice the sound in the daytime. There is also an audible ticking sound with the clock, but I find that soothing rather than annoying. This was probably an indication that the battery needed to be replaced soon. The backlight grew dimmer and dimmer as time went on too, to the point where, just last month, it didn't work at all. Some things to note for the long term: I don't know if I'm crazy, but I feel as if the alarm got a little less loud as time went on, but it was still plenty loud. Traditional alarm clocks are not nearly as loud or irritating as this is, which is a must if you're trying to get up at a certain time and don't want to accidentally sleep through your alarm. I've used several alarm clocks throughout my life, but this is by far one of the loudest I've used. Because of this, I've been using it only as a backup alarm set ten minutes after my phone alarm. ![]() My roommate hates the alarm, though (as it wakes her up, as well). This is definitely enough to wake a moderate to heavy sleeper up. I was satisfied enough with the clock that I ordered a new one, despite the clock being priced up to a whole $16.90! That's more than double what I paid when I originally bought the clock, so I did knock off a star for that. This caused the battery to leak and caused the clock to stop working. However, I recently switched to a college dorm and accidentally kicked my alarm clock down about four feet onto a hard tiled floor. I've dropped the alarm clock from my nightstand about a dozen times in the two years I've had it, and it's held up fine. Never had to change the battery either, so a little goes a long way. Batteries aren't included, so I did put in one AA battery when I received the clock two years ago. I bought this alarm clock for $7.88 two years ago. I would read the updated review below for more clear and detailed information. I also uploaded a quick video displaying the physical features of the clock. I used to have trouble waking up on time but not anymore.~ It's very loud and wakes up the entire household if it rings for long enough. It's inexpensive but does a good job in waking me up. ![]() ~It looks vintage and just like it does in the picture. ![]() Super fun soundboard app brings you the most beautiful tones, tunes and melodies for your smartphone! Check it out by downloading this amazing app right now! Get these "ringtones for free" and update you phone or any other kind of Android device you're using. * "Free Ringtones" are the "most popular funny ringtones" that you must have! * Compatible with 99% mobile phone devices * Completely free "mobile ringtones", this is the full version * Set as a ring tone, SMS notification alert, alarm sound or assign it to specific contacts * Easy to use interface: just tap once to listen to the sound and hold to set it * Includes 10 phone sound effects: dog sounds, coyote sounds, cow sounds, donkey sounds, chicken sounds, frog sounds, wolf sounds, goat sounds and other animal sound effects * High quality message tones, "ring tones" and funny sounds for your mobile phone * These are the best "free ringtones for Android", totally amazing and funny! You can set a different cool SMS alert tone for each contact from your phone! Super fun SMS sounds and call ring tones and tunes will put you in the center of attention every time your phone beeps! These "free ringtone downloads" are simply the best ringtones of 2015 on the market which can brighten up even the gloomiest day! Funny voice messages, old phone rings and other HQ ringtones resonating from your phone will make you cool and popular wherever you are! Grab this crazy app and breathe a new life into your Android phone - cheer up and LOL each time someone calls you or texts you! They feature a selection of "animal sounds" of all kinds: pet animals sounds, zoo animals sounds, wild animals sounds, and bird sounds. Time will tell whether ring tone sharing is something people want and whether the song upload requirement on copyrighted works will hold water.Are you ready for some "awesome ringtones"? Download this brand new app of 2015 and replace your default sound effects with "Free Ringtones" for Android. Emily Turrettini at Textually thinks PhoneZoo is “fabulous.” Carlo at TechDirt says PhoneZoo is headed for an uphill battle in the legal department. Oliver at MobileCrunch says there are many questions about the service’s viability that remain unanswered. ![]() PhoneZoo received a variety of coverage when it launched yesterday. The company is working on a widget that would let you display your most recent or favorite ring tones on a social networking site. The social element may or may not prove compelling. Best of all it’s relatively simple and it works. It’s all opt-in of course, there’s nothing enforcing any kind of copyright protection – no rights detection software apparently, for example. You can then make any changes you want, for example you might like the section of a song someone has excerpted but want to extend it by 2 seconds to capture another couple of beats. When you upload a copyrighted song, the ring tone creation tool opens with the same tone duration, title fields and excerpted section of your file as the ring tone you wanted to receive from some one else. It’s an interesting way to get around having PhoneZoo held responsible for copyright violations. Ringtones from copyrighted music can be listened to, discussed, searched for – but not downloaded until you upload a copy of the whole song yourself. Public domain files can be downloaded by anyone. On the copyright question, PhoneZoo lists two types of ring tones available for sharing. Metadata for sharing can be provided, copyright status of the file is asked and with one click a link to download the ring tone is sent to your phone. PhoneZoo scores high on ease of use, users set the duration of the tone and drag a marker over the segment of an audio file they want to excerpt. There are two things that are notable about the service the first is that unlike some other lightweight services like this PhoneZoo actually works, the second is how the company handles use of copyrighted music. The company’s early investors include Tim Draper. PhoneZoo is a new service that allows you to upload any audio file, clip out a part of that file for a cell phone ring tone and share that with other users.
![]() “Rainfall will average 0.25 to 0.75 inches with localized 1 inch totals possible. “A cold front will bring beneficial rainfall and a few non-severe thunderstorms to start off the new work week,” National Weather Service Boston tweeted. Weather Forecast for June 17 in Boston, Massachusetts - temperature, wind, atmospheric pressure, humidity and precipitations. Simpson said the Bay State is in “dire need” of some rain and that will be coming to start the week. “We won’t see any prolonged heat event with a three-day official heat wave.” “No real super oppressive heat on the way,” said Bill Simpson, meteorologist at the National Weather Service’s Boston office, following the hot and humid Sunday. 27, 2021.īut after Sunday’s heater, a cold front is expected to drop temps and bring some much-needed rain to the region that faces a drought. ![]() This material may not be published, broadcast, rewritten or redistributed without permission.The streak of no 90-degree days recorded at Boston Logan International Airport has been snapped after 302 days, according to the National Weather Service.īefore temps soared to 90 degrees on Sunday, the last 90-degree day reported from the Hub’s climate site was Aug. ![]() Three CSX employees have died on the job since June, prompting unions to call for better training and a review of the use of remote-control locomotives.ĬSX said its expenses declined 2% to $2.28 billion.ĬSX is one of the nation’s largest railroads, operating trains on more than 20,000 miles (32,000 kilometers) of track in 23 Eastern states and two Canadian provinces.Ĭopyright 2023 The Associated Press. Afternoon high temperatures continue to warm from the lower 70s F (21 C to 22 C) early in June to near 80 F (26 C to 27 C) by the month’s end. Revenue declined 8% to $3.57 billion at CSX as fuel surcharges and export coal prices both declined and shipments of the imported goods consumers want declined.ĬSX's new Chief Operating Officer Mike Cory said the railroad noticed an uptick in injuries and accidents involving new employees this year, so CSX increased the length of training new conductors receive and recruited a network of mentors to help teach them the craft after they finish their initial training. “Our commitment to them is not only to have class leading service, but to do our best to be repeatable and to be consistent.” June, July, August, September, October, November, December. “The reality is the railroads have not provided a consistent reliable service product to customers over time,” said Hinrichs, who joined the railroad a year ago. By most measures, CSX's performance is even better than it was before the pandemic. Hinrichs said customers are noticing that the railroad's service has been consistently better over the past year, and that is opening the door to more conversations about increasing the amount they ship on the railroad. “Over the third quarter, our efforts centered on delivering the reliable customer service that has allowed us to remain resilient and successfully maneuver through mixed markets,” said Joe Hinrichs, CSX president and chief executive officer. CSX improved the speed of its trains to an average of 17.6 mph in the quarter from 15.8 mph a year ago showing that its network was operating smoothly. The railroad's results show a mix of demand across various industries with a strong 19% jump in auto shipments and 9% growth in coal carloads nearly offsetting weak demand for consumer products and agricultural shipments. The results fell just short of the 43 cents per share that Wall Street was expecting, according to a survey of analysts done by FactSet Research. That's down from $1.1 billion, or 52 cents per share, a year ago. The Jacksonville, Florida-based railroad said it earned $846 million, or 42 cents per share, in the quarter. – CSX reported a 24% drop in the railroad's third-quarter profit Thursday as it hauled 2% less freight, but the CEO said customers are noticing that its trains are running more smoothly. ![]() The maple bonsai tree, along with all of its soil, should be removed from the pot. Repotting should be done in mid-summer, when the tree is at it’s least fragile state. Generally, this means every 2-3 years for a deciduous tree and every 4-5 years for an evergreen. If you can clearly see the roots coming out of the bottom of the pot, it’s time to repot your bonsai. Repotting must be performed periodically on your bonsai, Red Dragon Japanese maple included, when its root system has filled the pot. Trim back the new growth to the farthest safe point that looks good to you - but never remove all of the new growth.Ī regular trim will help keep your Red Dragon Japanese maple bonsai tree short, while helping the trunk grow thicker. A slow release (pellet based) fertilizer is perfect for this, and can be added sparingly every 1-2 months during the growing season. Since your Red Dragon Japanese maple bonsai is in a small pot, and not the ground, it needs nutrients. It will prevent the water from running on the floor, and can help keep the tree somewhat moist in the dry season. If you ever need to take your Red Dragon Japanese maple bonsai tree inside, including into a garage for the winter, using a humidity tray is recommended. If you need help, a good moisture meter will guide you. In the growing season, this can be daily. Whenever the soil seems dry, thoroughly water your tree until the water runs clear from the bottom. In the early spring, when the chance of freezing is gone, it can be placed back in its normal location.įor the rest of the year, the tree should be outside with a few hours of sun (morning sun, with afternoon shade is best.) Watering If you must, it can be placed in an unheated garage or shed.ĭo not forget to water your tree in the winter! The tree should be protected from strong wind and sun (but not snow or rain) throughout the winter. In the late fall, p rotect your tree by burying your tree, or mulch over the pot in the ground. It must stay cool or cold during the winter (about 3 months), but should be protected from harsh freezes. Like all deciduous trees, a Red Dragon Japanese maple bonsai should remain outdoors all year long. The Red Dragon Japanese maple is deciduous, meaning it will lose all foliage in the autumn (giving you incredible fall colors,) and be bare during winter months. This gives it another nickname: The Red Feather Japanese Maple. The leaves of the Red Dragon Japanese maple tree are its most defining feature: A luscious red with a feathery appearance. ![]() ![]() Acer Palmatum Dissectum Bonsai Care About The Red Dragon Japanese Maple Bonsai Tree ![]() The automotive industry is using SMS marketing to get in touch with prospective car buyers. □ Using the Email to Text add-on can benefit anyone in any industry, such as: Having an opt-in for SMS messaging allows you to send out promo material, sales events, and new product launch announcements quicker and easier than by email. Text messages from businesses get opened more often (80 to 100%) and are acted upon immediately. Using email to text to qualify your leads can help you speed up the process and increase your sales. Since texts have a higher conversion rate, it makes sense to use it as a way to move your customer from one part of your sales funnel to the next. ➤ Qualify More Leads with Two-way Messaging Encourage them to leave feedback in the way of a review to help others who may be on the fence. When consumers read online reviews of a product, they are more likely to purchase that product than if they had not read them.Ī great way to maximize on that would be to send out a survey by SMS after a customer interacts with your brand. Reviews are a great way to build your brand reputation online. ➤ SMS Can Help You Get More Product Reviews Texting can also facilitate the process with your sales team or customer support. Two things that can make you stand out from competitors. ➤ Engage With Customers and Have Conversations Over TextĬommunicating with customers helps your brand be more personable and approachable. The message doesn’t have to be long and you can customize it to relay the urgency or importance of your text. The response rates are considerably higher from SMS. People often respond to text messages more often than phone calls. ➤ Helps You Create a Sense of Urgency in Business Texting ✨ Benefits of Using Email to Text Add-on: Rogers: [cell phone [cell phone [cell phone [phone mobile: [phone [phone [phone [phone mobile company Sprint email to text: [phone (sms) / [phone (mms) Virgin mobile: [phone email to text: [phone (sms) / [phone (mms)Įmail to text Verizon: [phone (sms) / [phone (mms) □ Supported mobile carriers in the United States: Gateway addresses are convenient both for the sender and the recipient. SMS is transformed into an email or HTTP request, or vice versa. ➤ How do you know if a text message is spam?Īn SMS gateway is an interface that allows sending SMS without using a mobile device. Please don’t send any personal information to untrustworthy services, and don’t click any suspicious links or attachments. You can’t get hacked just by receiving or replying to a text message. ➤ Can you get hacked/scammed or get a virus by replying to a text message? If text messages were sent through our add-on, please respond with “stop” and we will prohibit the sender from sending messages to you. ➤ How do I stop/block an email address from texting me? ![]() Probably someone sent an email to or used Email to Text add-on. ![]() ➤ Why did I get a text message from an email? In case an error occurs, you will receive an email reply with an error description. ➤ How do I know if my text message was delivered? When using the Email to Text add-on, you don’t need to know cell phone provider information at all. ➤ How do you send a text message from email if you don't know the carrier? ➤ How do you send group text messages without showing all the phone numbers?Įvery contact is messaged separately by default, so no one will see other recipients. When a person responds to your text message, we will forward their SMS to you as an email. ➤ How will I receive a response from text to email? That’s exactly what you can do with our app! Just use your laptop or a desktop computer to send a text from Gmail™. ➤ How can I text from my computer without a cell phone? ★ We need your business information to verify your toll-free number with carriers. ★ You will get your own dedicate toll-free number to your business When a person answers your text, their reply will be sent to you as an email.īecause this add-on is natively implemented in Gmail, there is no need to install a Chrome extension or other software. Doing so will add recipients to your email in the format: Send your email by clicking “Send”. ![]() When all phone numbers are added, click on “save contacts”. Here you can add phone numbers from existing Google Contacts or add new ones.ĥ. Click on the "Email to Text" icon at the bottom of the draft window. In your Gmail account, click on “compose new”.Ĥ. Install the "Email to Text" add-on from Google Workspace.Ģ. ⭐ More than 90% of people read a text message within the first three minutes of receiving it!ġ. These weapons can then be picked up and used by the players.Īfter the benchmark-setting "Double Dragon", released by Technos in 1987, Final Fight would become the standard-bearer of the scrolling beat-em-up genre. Some of the Mad Gear gang members will drop a weapon when they are felled. Energy levels can be replenished by finding the food that lies hidden in certain crates and barrels. This move is powerful enough to fell several enemies at once, but with the trade-off that each time a special attack is executed, some of the player's energy is lost. ![]() As well as the standard punch and kick moves, each character also has a special attack. Set in the fictional Metro City, Haggar rounds up two of his closest friends, Guy and Cody, and sets out to battle Mad Gear's gang members and ultimately rescue his daughter.ġ or 2 players choose to play as either Guy, Cody or Haggar in this superb, sideways scrolling beat-em-up. Jessica, the daughter of the city Mayor Mike Haggar has been kidnapped by the evil 'Mad Gear' gang. Rabgno et al.įinal Fight (c) 1989 Capcom Company, Limited. Super Star Soldier (Tourvision PCE bootleg)Ĭredits Mameinfo and Mametesters Project Robert J. 25th April 1999: Dumped Omega Fighter Special. 8th November 2000: Yochizo sent in a driver for Omega Fighter and Atomic Robo-kid. ![]() 21st November 2000: Yochizo fixed some graphics bugs in the Omega Fighter / Atomic Robo-kid driver. 0.37b10: Yochizo added 'Omega Fighter' (UPL 1989) and clone Omega Fighter Special. ![]() 0.89u3: Changed Z80 CPU2 clock speed to 5MHz. After showing bad rom errors, the game resets. 0.147u2: hap fixed clone Omega Fighter Special. |
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